Phenylethylamine modulation of affect:
therapeutic and diagnostic implications

Sabelli HC; Javaid JI
Department of Psychiatry,
Rush Medical Center,
Chicago, IL 60612, USA.
J Neuropsychiatry Clin Neurosci 1995 Winter; 7(1):6-14


A review of the literature indicates that brain phenylethylamine (PEA) may be a neuromodulator of aminergic synapses and that it promotes energy, elevates mood, and favors aggression. Phenylacetic acid, the main metabolite of PEA, is decreased in the biological fluids of depressed subjects and schizophrenic subjects and is increased in schizoaffective subjects. The administration of PEA or of its precursor L-phenylalanine improves mood in depressed patients treated with a selective monoamine oxidase B inhibitor. The authors speculate that studies of PEA metabolism may have diagnostic value and that PEA administration may be therapeutic in selected depressed patients.

Brain imaging
PEA and mood
The brain in love
PEA and exercise
Food of the gods?
Chocolate hotlinks
Chocolate: history
PEA (from PiHKAL)
PEA and dopamine
Stoned chocaholics?
PEA and antidepressants
Chocolate: food or drug?
PEA and antidepressants
The endogenous amphetamine?