Sustained antidepressant
effect of PEA replacement

Sabelli H; Fink P; Fawcett J; Tom C
Rush University and the Center for
Creative Development, Chicago, Illinois, USA.
J Neuropsychiatry Clin Neurosci, 1996 Spr, 8:2, 168-71


Phenylethylamine (PEA), an endogenous neuroamine, increases attention and activity in animals and has been shown to relieve depression in 60% of depressed patients. It has been proposed that PEA deficit may be the cause of a common form of depressive illness. Fourteen patients with major depressive episodes that responded to PEA treatment (10-60 mg orally per day, with 10 mg/day selegiline to prevent rapid PEA destruction) were reexamined 20 to 50 weeks later. The antidepressant response had been maintained in 12 patients. Effective dosage did not change with time. There were no apparent side effects. PEA produces sustained relief of depression in a significant number of patients, including some unresponsive to the standard treatments. PEA improves mood as rapidly as amphetamine but does not produce tolerance.

The Chocuhaler
The brain in love
Chocolate: history
PEA (from PiHKAL)
PEA and dopamine
Stoned chocaholics?
Cacao/chocolate history
PEA and antidepressants
Chocolate: food or drug?
PEA and antidepressants
The endogenous amphetamine?
Doped horses/chocolate-coated peanuts
Do pregnant chocolate-eaters have sweet-natured kids?